DISCOVERY OF THE ELUSIVE UDP-DIACYLGLUCOSAMINE HYDROLASE IN THE LIPID A BIOSYNTHETIC PATHWAY IN CHLAMYDIA TRACHOMATIS

Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis

ABSTRACT Constitutive biosynthesis of lipid A via the Raetz pathway is essential for the viability and fitness of Gram-negative bacteria, including Chlamydia trachomatis.Although nearly all of the enzymes in the lipid A biosynthetic pathway are highly conserved across Gram-negative bacteria, the cleavage of the pyrophosphate group of UDP-2,3-diacyl

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Instability and fingering of interfaces in growing tissue

Interfaces in tissues are ubiquitous, both between tissue and environment as well as between populations of different cell types.The GROOMING CREAM propagation of an interface can be driven mechanically.Computer simulations of growing tissues are employed to study the stability of the interface between two tissues on a substrate.From a mechanical p

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